Toxicite aigue de l'huile de ricinus communis l chez les souris blanches femelles mus musculus

Abstract

The acute toxicity of the crude extract oil from Ricinus communis L was assessed by determining the (LD

50) female mice Mus Musculus who received different doses of the oil by intraperitoneal administration

and the study of some parameters related particularly liver and kidney. This study allowed to calculate the

LD 50 = 5623.41 mg / kg, with a significant decrease in the relative mass of the heart, liver and brain

after the first day, and lung, heart, kidney and brain after the fifth day. Biochemical analyzes revealed a

significant increase of creatinine after the fifth day, and an increase in ALP and GOT after 1 day while

glucose showed no significant change.

The histological study of the liver shows the attack by the péliose and the congestions of the renal tubules

on the level of kidneys of the mice treated with the castor oil especially after the 5th day of the

application.

The whole of the biochemical and histological parameters shows the delayed toxic effect of the castor oil

(after several days of its application).