http://dspace.univ-setif.dz:8888/jspui/handle/123456789/4 2026-08-22T08:51:21Z 2026-08-22T08:51:21Z KEBAILI, Hakima http://dspace.univ-setif.dz:8888/jspui/handle/123456789/6712 2026-07-16T09:04:57Z 2025-01-01T00:00:00Z

Titre: Ecotoxicologie végétale : (phytotoxicité et effets des substances toxiques) 3ème année licence en Biotechnologie et amélioration des plantes Auteur(s): KEBAILI, Hakima Résumé: Les essais d’écotoxicité sont le meilleur moyen de mesurer la teneur de la toxicité (Fig1). Ils ont pour objectif l’évaluation et la prévention des effets biologiques et le devenir des

2025-01-01T00:00:00Z HOUCHI, Selma http://dspace.univ-setif.dz:8888/jspui/handle/123456789/6711 2026-07-15T10:37:44Z 2026-01-01T00:00:00Z

Titre: Cellular and Molecular Immunology Master 2 Biotechnology and health Auteur(s): HOUCHI, Selma Résumé: Immunity encompasses the biological mechanisms that enable living organisms to recognize, resist, and eliminate foreign substances, particularly infectious agents, while maintaining tissue integrity and physiological homeostasis. The coordinated network of organs, tissues, cells, and soluble mediators involved in these protective processes constitutes the immune system. Together, these components generate highly regulated responses that protect the host against pathogens and other potentially harmful challenges. Immunology is the branch of biomedical science devoted to the study of the immune system, its components, and its functions. The origins of modern immunology are commonly traced to Edward Jenner, whose pioneering work on vaccination against smallpox in 1796 laid the foundation for one of the most significant advances in medical history. Since then, immunology has evolved into a multidisciplinary field that integrates molecular biology, genetics, microbiology, biotechnology, and clinical medicine. Although initially focused on host defense against infectious diseases, immunology now plays a central role in understanding a wide range of physiological and pathological processes. Advances in immunological research have revealed the involvement of the immune system in allergy, autoimmunity, chronic inflammation, transplantation, cancer, metabolic disorders, and tissue repair. Consequently, immunology has become an essential discipline for both fundamental biological research and modern healthcare. The immune system represents a remarkably sophisticated and dynamic network that has evolved to provide efficient protection while maintaining self-tolerance. Understanding its cellular and molecular mechanisms is essential for deciphering the pathogenesis of numerous human diseases and for developing innovative diagnostic, preventive, and therapeutic strategies. This course provides an in-depth study of the cellular and molecular mechanisms governing immune responses. Particular emphasis is placed on the development, activation, regulation, and functional specialization of immune cells, as well as on their applications in biotechnology and health sciences. By the end of this course, students will possess a comprehensive understanding of immune system organization and function, enabling them to apply immunological concepts to research, biotechnology, and biomedical innovation.

2026-01-01T00:00:00Z HOUCHI, Selma http://dspace.univ-setif.dz:8888/jspui/handle/123456789/6710 2026-07-15T10:39:56Z 2026-01-01T00:00:00Z

Titre: Drug discovry and development : Master 1 Pharmaco-Toxicology Auteur(s): HOUCHI, Selma Résumé: The course "Drug Design and Development" is designed for first-year Master’s students in pharmaco-toxicology option. It offers a comprehensive overview of the modern drug development process, from target identification to clinical trials and regulatory approval. The main objective of the course is to provide students with a clear understanding of how new drugs are discovered, designed, optimized, and brought to market. Emphasis is placed on both theoretical principles and practical applications, preparing students for future research or industry roles. The course begins with an introduction to drug discovery, including a historical overview and the classification of drug types and molecular targets such as enzymes, receptors, and nucleic acids. It then explores methods for target identification and validation using in silico, in vitro, and in vivo approaches. Students will learn about various strategies for identifying lead compounds , including high-throughput screening, rational drug design, and the use of natural products. The process of lead optimization is covered in detail, focusing on structure-activity relationships (SAR) and ADMET properties, which are crucial for ensuring efficacy and safety. The course also covers preclinical development, including pharmacokinetics, pharmacodynamics, and toxicological testing in animal models. This is followed by an in-depth look at clinical development, outlining the four phases of clinical trials, study design, ethical considerations, and data analysis. Regulatory frameworks are discussed, with attention given to agencies like the FDA (Food and Drug Administration) and EMA (European Medicines Agency), and the requirements for submitting investigational new drug (IND) and new drug application (NDA) dossiers. Finally, the course highlights emerging trends and challenges in the field, such as the integration of artificial intelligence in drug discovery, personalized medicine, and the development of treatments for rare diseases.

2026-01-01T00:00:00Z HOUCHI, Selma http://dspace.univ-setif.dz:8888/jspui/handle/123456789/6709 2026-07-15T10:40:22Z 2024-01-01T00:00:00Z

Titre: Handout Production of biomolecules in animal cell systems Designed for first-year Master's students Option: Biotechnology and molecular pathology Auteur(s): HOUCHI, Selma Résumé: The production and extraction of biomolecules from animal cells are crucial processes in biotechnology, biochemistry, and medicine. These biomolecules, including proteins, enzymes, antibodies, and hormones, are essential for various applications ranging from fundamental research to drug development. The world of biomolecules is a complex riddle! The pieces are numerous, some are well-known, others less so... The course on Production of biomolecules in animal cell systems provides a detailed understanding of the methods used in the production and extraction of valuable molecules such as insulin, interferons, and erythropoietin, as well as their structure, biosynthesis, role, and regulation. Studying this course involves being able to identify the mechanism behind a wide range of human diseases. Comprehending better has not only revolutionized medicine and biotechnology, but has also paved the way for new possibilities in the treatment of various diseases.

2024-01-01T00:00:00Z